Negative regulation of protein localization to chromatin

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein localization to chromatin pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A26, AGR2, and CLK4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein localization to chromatin activity versus SLC25A26 in SKIN (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC25A26 →	-0.608	-0.194	.006	.003	3	4
UPPER_AERODIGESTIVE_TRACT	AGR2 →	+2.184	+0.157	.004	.007	2	4
SKIN	CLK4 →	-0.654	-0.228	.004	.003	3	3
SKIN	HESX1 →	-0.518	-0.259	<.001	<.001	3	3
SKIN	ANKRD36C →	-0.630	-0.163	<.001	.005	3	3
BREAST	ANKRD36B →	-0.823	-0.130	.003	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120186 vs SLC25A26 — SKIN

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