Steroid hormone biosynthetic process

Across TCGA patient cohorts, RNA activity of the Steroid hormone biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRPX2, PLS3, and ECM2_S213, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Steroid hormone biosynthetic process activity versus SRPX2 in CCRCC (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SRPX2 →	+0.745	+0.051	<.001	<.001	3	6
BRCA	PLS3 →	+0.524	+0.032	<.001	<.001	3	6
CCRCC	ECM2_S213 →	+0.944	+0.046	.001	<.001	3	6
LSCC	BCL3_S41 →	-0.381	-0.035	<.001	<.001	3	5
CCRCC	BGN →	+0.594	+0.037	<.001	<.001	3	5
OV	SEPTIN4 →	+0.451	+0.025	.002	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120178 vs SRPX2 — CCRCC

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