Steroid hormone biosynthetic process

Across TCGA cell cohorts, RNA activity of the Steroid hormone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JAZF1, AIMP1, and PRSS16, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Steroid hormone biosynthetic process activity versus JAZF1 in SKIN (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	JAZF1 →	+1.094	+0.221	.001	.002	3	5
BONE	AIMP1 →	+0.412	+0.398	.006	.002	3	4
SOFT_TISSUE	PRSS16 →	-1.772	-0.372	.001	<.001	3	4
SOFT_TISSUE	CDK14 →	+2.205	+0.292	.009	.001	3	4
SOFT_TISSUE	IL27RA →	-1.760	-0.292	.008	.001	2	5
SOFT_TISSUE	ZSWIM3 →	+0.946	+0.407	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120178 vs JAZF1 — SKIN

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