Negative regulation of cold-induced thermogenesis

Across TCGA patient cohorts, RNA activity of the Negative regulation of cold-induced thermogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP1R12C, GNG2, and SRPK1_S311, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cold-induced thermogenesis activity versus PPP1R12C in BRCA (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PPP1R12C →	+0.283	+0.031	<.001	<.001	3	6
BRCA	GNG2 →	+0.334	+0.017	<.001	.002	3	6
CCRCC	SRPK1_S311 →	-0.307	-0.038	<.001	.005	3	6
OV	YTHDC1_S308 →	-0.794	-0.030	.003	.003	3	5
BRCA	ADH5 →	+0.349	+0.023	<.001	.006	3	5
BRCA	ILK →	+0.387	+0.023	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120163 vs PPP1R12C — BRCA

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