Negative regulation of cold-induced thermogenesis

Across TCGA patient cohorts, RNA activity of the Negative regulation of cold-induced thermogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HDAC1, TSHZ1, and GSTM2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cold-induced thermogenesis activity versus HDAC1 in PDAC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HDAC1 →	+0.284	+0.169	.002	.001	3	3
CCRCC	TSHZ1 →	+0.351	+0.156	.001	.007	3	3
BRCA	GSTM2 →	+0.599	+0.218	.002	.001	3	3
BRCA	BTNL9 →	+0.874	+0.288	.002	.004	3	3
BRCA	MRPS31P5 →	+0.235	+0.346	.006	.003	3	3
CCRCC	LINC00622 →	+0.548	+0.176	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120163 vs HDAC1 — PDAC

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