Negative regulation of cold-induced thermogenesis

Across TCGA cell cohorts, RNA activity of the Negative regulation of cold-induced thermogenesis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STON2, RPS6KA3, and SLC12A9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STON2 grouped by Negative regulation of cold-induced thermogenesis-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	STON2 →	+0.913	+1.023	.008	<.001	3	4
SOFT_TISSUE	RPS6KA3 →	+1.575	+0.841	<.001	.007	3	4
STOMACH	SLC12A9 →	-1.296	-1.246	<.001	.004	3	3
STOMACH	ZNF394 →	-0.439	-0.854	.007	.001	3	3
KIDNEY	DDB2 →	-1.336	-1.278	.001	.001	3	3
KIDNEY	PPP1R18 →	+0.759	+1.238	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STON2 by Negative regulation of cold-induced thermogenesis activity — SOFT_TISSUE

Explore this box plot interactively →