Positive regulation of cold-induced thermogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of cold-induced thermogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERPINE1, LGALS1, and KATNAL1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SERPINE1 grouped by Positive regulation of cold-induced thermogenesis-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SERPINE1 →	-5.161	-0.300	.002	.001	3	7
PANCREAS	LGALS1 →	-2.409	-0.333	.002	<.001	3	6
LARGE_INTESTINE	KATNAL1 →	-1.480	-0.215	<.001	<.001	3	6
PANCREAS	STARD9 →	-0.909	-0.300	.001	<.001	3	5
PANCREAS	ITGBL1 →	-3.140	-0.232	<.001	.004	3	5
LARGE_INTESTINE	DCBLD2 →	-3.788	-0.212	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SERPINE1 by Positive regulation of cold-induced thermogenesis activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →