Positive regulation of cold-induced thermogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of cold-induced thermogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SQOR, DZIP1, and PPP2R1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cold-induced thermogenesis activity versus SQOR in LUNG_NSCLC_LUAD (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SQOR →	-1.720	-0.219	<.001	<.001	3	5
OESOPHAGUS	DZIP1 →	+2.482	+0.319	.009	.001	3	4
PANCREAS	PPP2R1B →	-0.905	-0.193	.004	.001	2	5
PANCREAS	CHEK1 →	-1.235	-0.190	.002	.008	3	4
PANCREAS	RRM1 →	-1.076	-0.210	.003	<.001	3	4
LUNG_NSCLC_LUSC	FDPS →	-0.686	-0.302	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120162 vs SQOR — LUNG_NSCLC_LUAD

Explore this scatter interactively →