Response to zinc ion starvation

Across TCGA cell cohorts, RNA activity of the Response to zinc ion starvation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHLDB2, RNFT1, and NHS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PHLDB2 grouped by Response to zinc ion starvation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PHLDB2 →	-2.243	-0.917	.002	.004	3	5
OESOPHAGUS	RNFT1 →	+1.260	+1.594	.003	<.001	2	6
SKIN	NHS →	-0.998	-1.034	.005	.004	3	4
BREAST	PTRH2 →	+0.783	+0.732	.001	.003	3	4
BLOOD_Leukemia	EHD3 →	-1.690	-1.025	.007	<.001	3	4
URINARY_TRACT	RPL8 →	+1.036	+1.796	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHLDB2 by Response to zinc ion starvation activity — BREAST

Explore this box plot interactively →