Regulation of macrophage proliferation

Across TCGA patient cohorts, RNA activity of the Regulation of macrophage proliferation pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRB1, LILRA1, and C3AR1, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of macrophage proliferation activity versus LILRB1 in UCS (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	LILRB1 →	+1.445	+0.112	<.001	<.001	3	32
LAML	LILRA1 →	+1.093	+0.067	<.001	<.001	3	31
UCS	C3AR1 →	+1.518	+0.086	<.001	<.001	3	31
CHOL	CSF2RB →	+1.694	+0.102	<.001	<.001	3	30
UCS	CD300C →	+1.257	+0.085	<.001	.003	3	30
UCS	FPR3 →	+1.585	+0.091	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120040 vs LILRB1 — UCS

Explore this scatter interactively →