Regulation of macrophage proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of macrophage proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGF2, DZANK1, and KBTBD7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IGF2 grouped by Regulation of macrophage proliferation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	IGF2 →	+1.553	+0.579	.004	.007	3	4
BLOOD_Lymphoma	DZANK1 →	+2.588	+0.445	.001	.003	2	5
PANCREAS	KBTBD7 →	+0.708	+0.837	.006	.008	2	4
OESOPHAGUS	ARID3A →	+2.211	+1.147	<.001	.008	3	3
CNS	VWDE →	-1.098	-1.400	.007	<.001	3	3
CNS	IFNE →	-0.668	-0.853	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IGF2 by Regulation of macrophage proliferation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →