Regulation of macrophage proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of macrophage proliferation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KAT7, INTS8, and MTBP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of macrophage proliferation activity versus KAT7 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	KAT7 →	+0.827	+1.769	.002	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	INTS8 →	+1.682	+1.808	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	MTBP →	+1.166	+1.345	.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	TANGO6 →	+1.152	+1.868	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	KIF1C →	+0.971	+1.394	.007	.003	3	4
UPPER_AERODIGESTIVE_TRACT	AP1AR →	+0.605	+1.454	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120040 vs KAT7 — UPPER_AERODIGESTIVE_TRACT

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