Positive regulation of plasma membrane bounded cell projection assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of plasma membrane bounded cell projection assembly pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR7845, VIPR1, and ARHGAP40, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of plasma membrane bounded cell projection assembly activity versus MIR7845 in CCRCC (Pearson r = -0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MIR7845 →	-1.222	-0.111	.006	.001	3	2
BRCA	VIPR1 →	+1.029	+0.162	.005	.006	3	2
BRCA	ARHGAP40 →	+2.599	+0.211	.001	.001	3	2
BRCA	KCNJ11 →	+1.422	+0.249	.003	.004	3	2
BRCA	VSIG2 →	+2.444	+0.248	.002	.005	3	2
BRCA	FBXL22 →	+0.631	+0.194	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120034 vs MIR7845 — CCRCC

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