Positive regulation of plasma membrane bounded cell projection assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of plasma membrane bounded cell projection assembly pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SETD1A, POLRMT, and SOX12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SETD1A grouped by Positive regulation of plasma membrane bounded cell projection assembly-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SETD1A →	-0.805	-0.381	.004	<.001	2	6
SKIN	POLRMT →	-0.646	-0.467	<.001	.007	3	5
OESOPHAGUS	SOX12 →	-1.183	-0.260	.001	<.001	3	4
LARGE_INTESTINE	BRD4 →	-0.494	-0.292	.005	.007	3	4
PANCREAS	ZNF771 →	-0.927	-0.336	.003	.001	3	4
LARGE_INTESTINE	FEM1A →	-0.616	-0.278	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SETD1A by Positive regulation of plasma membrane bounded cell projection assembly activity — LIVER

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