Positive regulation of plasma membrane bounded cell projection assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of plasma membrane bounded cell projection assembly pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNAI2, PDZD11, and SERPINB8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of plasma membrane bounded cell projection assembly activity versus GNAI2 in LIVER (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GNAI2 →	+1.297	+0.251	.008	.004	3	6
LUNG_NSCLC_LUAD	PDZD11 →	+0.730	+0.153	<.001	.002	3	6
BLOOD_Myeloma	SERPINB8 →	+2.086	+0.311	<.001	.004	3	5
PANCREAS	RASA3 →	+2.188	+0.321	.001	.002	3	5
BLOOD_Leukemia	ARPC2 →	+0.674	+0.097	.003	.004	3	5
LIVER	MDFIC →	+1.717	+0.223	.005	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120034 vs GNAI2 — LIVER

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