Negative regulation of plasma membrane bounded cell projection assembly

Across TCGA patient cohorts, RNA activity of the Negative regulation of plasma membrane bounded cell projection assembly pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSIP1, RPL4, and ADH1C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of plasma membrane bounded cell projection assembly activity versus PSIP1 in GBM (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PSIP1 →	+0.497	+0.047	.004	.001	3	6
BRCA	RPL4 →	-0.472	-0.034	<.001	<.001	3	6
OV	ADH1C →	+1.298	+0.031	.008	.001	2	6
BRCA	MRPL51 →	-0.377	-0.028	<.001	<.001	3	5
OV	RPL10 →	-0.302	-0.035	.004	<.001	3	5
OV	RPL5 →	-0.171	-0.040	.007	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120033 vs PSIP1 — GBM

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