Negative regulation of plasma membrane bounded cell projection assembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of plasma membrane bounded cell projection assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTLL4, ZNF18, and ANKRD62, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TTLL4 grouped by Negative regulation of plasma membrane bounded cell projection assembly-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TTLL4 →	-0.213	-0.331	<.001	<.001	3	3
SOFT_TISSUE	ZNF18 →	-0.215	-0.294	.009	.001	3	3
LUNG_NSCLC_LUAD	ANKRD62 →	-0.194	-0.309	.008	.003	3	3
LUNG_NSCLC_LUAD	CAPZB →	-0.374	-0.412	<.001	<.001	3	3
SKIN	TBC1D3E →	-0.205	-0.753	<.001	.004	3	3
LUNG_SCLC	TCHP →	-0.262	-1.065	<.001	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TTLL4 by Negative regulation of plasma membrane bounded cell projection assembly activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →