Negative regulation of plasma membrane bounded cell projection assembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of plasma membrane bounded cell projection assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NABP2, CORT, and TRIM67, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of plasma membrane bounded cell projection assembly activity versus NABP2 in BLOOD_Lymphoma (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NABP2 →	+0.638	+0.208	.002	<.001	3	6
KIDNEY	CORT →	-0.226	-0.227	.002	.007	3	4
BREAST	TRIM67 →	-0.057	-0.255	.008	<.001	2	5
SKIN	MRPS16 →	+0.456	+0.189	.001	.003	3	4
SOFT_TISSUE	NAGLU →	-0.826	-0.214	<.001	.004	3	4
PANCREAS	POP5 →	+0.868	+0.318	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120033 vs NABP2 — BLOOD_Lymphoma

Explore this scatter interactively →