Intermembrane lipid transfer

Across TCGA patient cohorts, RNA activity of the Intermembrane lipid transfer pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZEB2_T34, CD5_S428, and PIP4P2_T22, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intermembrane lipid transfer activity versus ZEB2_T34 in PDAC (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ZEB2_T34 →	-0.296	-0.035	<.001	.003	3	4
PDAC	CD5_S428 →	-0.412	-0.036	.004	<.001	3	4
PDAC	PIP4P2_T22 →	+0.661	+0.052	.002	.002	3	4
LSCC	SPEN_T1140 →	-0.396	-0.025	.005	.009	3	4
GBM	MAP3K1_S21 →	-0.646	-0.080	<.001	<.001	3	4
UCEC	TMX1_S247 →	-0.567	-0.054	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120009 vs ZEB2_T34 — PDAC

Explore this scatter interactively →