Intermembrane lipid transfer

Across TCGA patient cohorts, RNA activity of the Intermembrane lipid transfer pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAPOLG, LAYN, and HACE1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intermembrane lipid transfer activity versus PAPOLG in CCRCC (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PAPOLG →	-0.225	-0.486	.001	<.001	3	3
CCRCC	LAYN →	-0.620	-0.466	.002	<.001	3	3
CCRCC	HACE1 →	-0.349	-0.466	<.001	<.001	3	3
LUAD	CEBPZ →	-0.238	-0.202	.002	.003	3	3
LUAD	QRSL1 →	-0.198	-0.238	.002	<.001	3	3
LUAD	ODF3B →	+0.562	+0.329	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120009 vs PAPOLG — CCRCC

Explore this scatter interactively →