Intermembrane lipid transfer

Across TCGA cell cohorts, RNA activity of the Intermembrane lipid transfer pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNMB3, OGFR, and OSBPL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNMB3 grouped by Intermembrane lipid transfer-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	KCNMB3 →	-0.822	-1.499	<.001	<.001	3	5
LARGE_INTESTINE	OGFR →	-0.988	-1.205	.009	.002	3	5
LARGE_INTESTINE	OSBPL3 →	-1.082	-1.071	.003	.002	3	4
BREAST	IGFALS →	-0.261	-1.153	.006	<.001	3	4
BLOOD_Myeloma	SLCO1A2 →	-2.050	-1.562	.002	.007	3	4
LUNG_NSCLC_LUAD	MFSD11 →	-0.534	-0.980	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNMB3 by Intermembrane lipid transfer activity — KIDNEY

Explore this box plot interactively →