Intermembrane lipid transfer

Across TCGA cell cohorts, RNA activity of the Intermembrane lipid transfer pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VAT1, CNTNAP1, and DNTTIP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intermembrane lipid transfer activity versus VAT1 in LUNG_SCLC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	VAT1 →	+1.053	+0.891	.002	.001	3	8
OESOPHAGUS	CNTNAP1 →	+1.307	+0.630	.002	.004	3	4
BLOOD_Lymphoma	DNTTIP1 →	+0.673	+0.904	.002	.001	3	4
BLOOD_Myeloma	RCBTB2 →	-1.914	-1.111	.003	.003	3	4
LIVER	GLTP →	-1.135	-0.568	.006	.006	3	4
BLOOD_Leukemia	TMEM243 →	-0.957	-0.506	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120009 vs VAT1 — LUNG_SCLC

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