mRNA methylguanosine-cap decapping

Across TCGA patient cohorts, RNA activity of the mRNA methylguanosine-cap decapping pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DCPS, PHF2_S905, and UBE2J2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA methylguanosine-cap decapping activity versus DCPS in UCEC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DCPS →	+0.223	+0.051	<.001	.003	3	6
CCRCC	PHF2_S905 →	+0.515	+0.029	.001	.008	3	5
CCRCC	UBE2J2 →	-0.648	-0.034	.001	<.001	3	5
LUAD	SCAF1_S874 →	+0.199	+0.018	.009	.008	3	5
HNSC	BIN2_S444 →	-0.663	-0.087	.002	.001	3	5
LUAD	GPS1_S474 →	-0.393	-0.033	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110156 vs DCPS — UCEC

Explore this scatter interactively →