mRNA methylguanosine-cap decapping

Across TCGA patient cohorts, RNA activity of the mRNA methylguanosine-cap decapping pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNS2, BMERB1, and NTN4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA methylguanosine-cap decapping activity versus TNS2 in CCRCC (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TNS2 →	-0.541	-0.537	.001	.007	3	4
LSCC	BMERB1 →	-0.622	-0.298	<.001	.001	3	3
CCRCC	NTN4 →	-1.203	-0.767	<.001	<.001	3	3
CCRCC	PSMD14 →	+0.263	+0.478	.003	.003	3	3
CCRCC	PLCL1 →	-0.651	-0.705	<.001	<.001	3	3
CCRCC	ALDH6A1 →	-0.749	-0.726	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110156 vs TNS2 — CCRCC

Explore this scatter interactively →