mRNA methylguanosine-cap decapping

Across TCGA cell cohorts, RNA activity of the mRNA methylguanosine-cap decapping pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFP90, TMEM106C, and IL17RC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZFP90 grouped by mRNA methylguanosine-cap decapping-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ZFP90 →	+0.974	+0.435	.005	.006	3	4
PANCREAS	TMEM106C →	-0.798	-0.427	.001	<.001	3	4
LARGE_INTESTINE	IL17RC →	-0.784	-0.529	<.001	.004	3	4
LIVER	CELF6 →	-0.403	-0.473	.001	.003	3	3
CNS	TSPAN33 →	-1.295	-0.308	.004	.009	3	3
CNS	POLR2J →	-0.459	-0.379	.002	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZFP90 by mRNA methylguanosine-cap decapping activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →