mRNA methylguanosine-cap decapping

Across TCGA cell cohorts, RNA activity of the mRNA methylguanosine-cap decapping pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOB1, TAF4, and BTBD2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA methylguanosine-cap decapping activity versus NOB1 in OVARY (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NOB1 →	+1.074	+0.282	.005	.009	3	7
LARGE_INTESTINE	TAF4 →	+0.728	+0.240	.002	.008	2	7
SOFT_TISSUE	BTBD2 →	+1.237	+0.352	.001	.004	3	6
STOMACH	THBS1 →	-3.106	-0.263	.002	.005	3	5
OVARY	CPA4 →	-2.275	-0.225	.007	.004	3	5
LUNG_SCLC	CSNK2A2 →	+0.597	+0.186	.004	.003	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110156 vs NOB1 — OVARY

Explore this scatter interactively →