RNA decapping

Across TCGA patient cohorts, RNA activity of the RNA decapping pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNS2, HSPA12B, and ITGA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA decapping activity versus TNS2 in CCRCC (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TNS2 →	-0.673	-0.594	.001	.002	3	4
CCRCC	HSPA12B →	-0.800	-0.562	.002	.007	3	4
CCRCC	ITGA2 →	-0.667	-0.613	.004	.001	3	4
CCRCC	SLC9A3R2 →	-0.887	-0.585	<.001	.005	2	5
CCRCC	NPM3 →	+0.355	+0.472	.009	.008	3	3
CCRCC	ALDH6A1 →	-0.639	-0.405	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110154 vs TNS2 — CCRCC

Explore this scatter interactively →