RNA decapping

Across TCGA cell cohorts, RNA activity of the RNA decapping pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIMD2, EIF4EBP1, and ERI1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA decapping activity versus LIMD2 in BONE (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	LIMD2 →	+2.574	+0.311	.001	.005	3	5
BONE	EIF4EBP1 →	+1.728	+0.399	<.001	<.001	3	5
LARGE_INTESTINE	ERI1 →	+0.856	+0.221	.006	.001	3	5
LARGE_INTESTINE	TAF4 →	+0.734	+0.242	.001	.002	3	5
OESOPHAGUS	KRT13 →	-3.620	-0.188	.002	.008	3	4
BLOOD_Myeloma	AASDHPPT →	+0.825	+0.263	.005	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110154 vs LIMD2 — BONE

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