Regulation of lipid transporter activity

pathway activity — cross-omics
GO:0110112Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Regulation of lipid transporter activity pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFBR2, LYVE1, and VSIG4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCTGFBR2 →+0.558+0.120<.001<.00136
BRCALYVE1 →+1.040+0.162<.001.00135
GBMVSIG4 →+1.024+0.338.001<.00135
GBMALOX5 →+0.855+0.333<.001<.00135
GBMHLX →+0.436+0.263<.001<.00135
GBMPRKCD →+0.564+0.222<.001.00335
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration