Positive regulation of animal organ morphogenesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of animal organ morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADD3, RRP36_S73, and ADD1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of animal organ morphogenesis activity versus ADD3 in GBM (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ADD3 →	+0.419	+0.050	<.001	<.001	3	8
BRCA	RRP36_S73 →	-0.562	-0.040	.004	<.001	3	7
GBM	ADD1 →	+0.345	+0.043	<.001	<.001	3	7
UCEC	CDK12_S1083 →	-0.375	-0.068	<.001	<.001	3	7
BRCA	HMCN1 →	+0.812	+0.053	<.001	<.001	3	7
LUAD	DDX21_S71 →	-1.434	-0.064	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110110 vs ADD3 — GBM

Explore this scatter interactively →