Regulation of hippocampal neuron apoptotic process

Across TCGA patient cohorts, RNA activity of the Regulation of hippocampal neuron apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UTP20_T1741, CDK12_S1083, and SNRNP200, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hippocampal neuron apoptotic process activity versus UTP20_T1741 in BRCA (Pearson r = -0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	UTP20_T1741 →	-0.393	-0.073	<.001	<.001	3	5
UCEC	CDK12_S1083 →	-0.355	-0.110	<.001	.003	3	5
BRCA	SNRNP200 →	-0.133	-0.064	<.001	<.001	3	5
BRCA	USP39 →	-0.224	-0.082	<.001	<.001	3	5
UCEC	CTNNBL1 →	-0.129	-0.083	.008	.004	3	5
CCRCC	AHCTF1 →	-0.147	-0.100	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110089 vs UTP20_T1741 — BRCA

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