Regulation of hippocampal neuron apoptotic process

Across TCGA patient cohorts, RNA activity of the Regulation of hippocampal neuron apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACKR2, ANKRD29, and CBX1P2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hippocampal neuron apoptotic process activity versus ACKR2 in UCEC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACKR2 →	+1.355	+0.568	.002	.001	3	3
GBM	ANKRD29 →	+0.570	+0.715	.001	.002	3	3
GBM	CBX1P2 →	+0.652	+0.750	<.001	<.001	3	3
LUAD	MIR4636 →	-0.647	-0.451	.002	.005	3	3
BRCA	ASCC3 →	-0.584	-0.613	<.001	.002	3	3
LSCC	RWDD2A →	-0.363	-0.559	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110089 vs ACKR2 — UCEC

Explore this scatter interactively →