Regulation of hippocampal neuron apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of hippocampal neuron apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED28, ZDHHC24, and TRIM24, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MED28 grouped by Regulation of hippocampal neuron apoptotic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MED28 →	+0.398	+0.852	.002	.007	3	4
LUNG_SCLC	ZDHHC24 →	+0.661	+1.144	.001	.006	3	3
BONE	TRIM24 →	+0.870	+1.594	.005	<.001	3	3
OESOPHAGUS	CFD →	+1.592	+0.909	.004	.001	3	3
BLOOD_Myeloma	FAM193B →	+1.259	+0.502	.002	.003	3	3
KIDNEY	MAT2B →	+0.485	+1.180	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MED28 by Regulation of hippocampal neuron apoptotic process activity — OESOPHAGUS

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