Regulation of hippocampal neuron apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of hippocampal neuron apoptotic process pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CASP8, RAB40A, and MAGEB10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CASP8 grouped by Regulation of hippocampal neuron apoptotic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CASP8 →	-0.341	-2.113	.007	.001	3	4
LUNG_SCLC	RAB40A →	-0.284	-0.185	.001	.002	3	4
BLOOD_Lymphoma	MAGEB10 →	+0.447	+1.988	.005	<.001	3	3
BLOOD_Lymphoma	GPR39 →	-0.475	-1.997	.002	<.001	3	3
BREAST	CAPZB →	+0.381	+1.062	.007	.003	3	3
BREAST	REV3L →	+0.232	+1.212	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CASP8 by Regulation of hippocampal neuron apoptotic process activity — STOMACH

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