Regulation of hippocampal neuron apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of hippocampal neuron apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELF3, LCN2, and B3GNT3, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hippocampal neuron apoptotic process activity versus ELF3 in URINARY_TRACT (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ELF3 →	+5.461	+1.706	<.001	.001	3	15
PANCREAS	LCN2 →	+7.323	+1.134	<.001	<.001	3	13
URINARY_TRACT	B3GNT3 →	+3.200	+1.607	<.001	<.001	3	13
OVARY	PDZK1IP1 →	+3.708	+1.342	<.001	<.001	3	13
OVARY	TACSTD2 →	+5.489	+1.615	<.001	<.001	3	13
URINARY_TRACT	IL1RN →	+2.501	+1.173	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110089 vs ELF3 — URINARY_TRACT

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