Hippocampal neuron apoptotic process

pathway activity — cross-omics
GO:0110088Cross-omicsRNA → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Hippocampal neuron apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TREM2, TMIGD3, and FCGR3A, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
THYMTREM2 →+2.494+0.120<.001<.001328
CHOLTMIGD3 →+1.067+0.076<.001<.001324
THYMFCGR3A →+2.260+0.098<.001<.001324
SCLCSLC15A3 →+1.941+0.159<.001<.001323
LAMLSIGLEC9 →+1.240+0.065<.001<.001323
LAMLITGAX →+1.428+0.082<.001<.001323
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration