Regulation of actin filament organization

Across TCGA cell cohorts, RNA activity of the Regulation of actin filament organization pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AMOTL1, NOXO1, and STC2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AMOTL1 grouped by Regulation of actin filament organization-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	AMOTL1 →	+1.371	+1.554	<.001	<.001	3	4
LARGE_INTESTINE	NOXO1 →	-1.140	-0.649	.009	.001	3	3
SOFT_TISSUE	STC2 →	+4.814	+1.589	<.001	<.001	3	3
SOFT_TISSUE	TEX15 →	-0.795	-1.070	.007	<.001	3	3
SOFT_TISSUE	SLFN5 →	+1.692	+1.257	.004	<.001	3	3
SOFT_TISSUE	SLC5A3 →	-1.388	-0.989	.005	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AMOTL1 by Regulation of actin filament organization activity — BONE

Explore this box plot interactively →