Regulation of G2/MI transition of meiotic cell cycle

Across TCGA patient cohorts, RNA activity of the Regulation of G2/MI transition of meiotic cell cycle pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLGAP5, CDC45, and CDC6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of G2/MI transition of meiotic cell cycle activity versus DLGAP5 in GBM (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DLGAP5 →	+1.006	+0.375	.001	.002	3	6
GBM	CDC45 →	+0.900	+0.416	.001	.001	3	6
LSCC	CDC6 →	+1.088	+0.449	<.001	<.001	3	6
BRCA	CYBRD1 →	-1.560	-0.347	.001	.002	3	5
BRCA	CDKN3 →	+0.717	+0.213	.003	<.001	3	5
BRCA	GINS1 →	+0.803	+0.269	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110030 vs DLGAP5 — GBM

Explore this scatter interactively →