Regulation of G2/MI transition of meiotic cell cycle

Across TCGA cell cohorts, RNA activity of the Regulation of G2/MI transition of meiotic cell cycle pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPAP1, TMEM45A, and MLF2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPAP1 grouped by Regulation of G2/MI transition of meiotic cell cycle-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RPAP1 →	+0.385	+0.084	.005	.009	3	4
SOFT_TISSUE	TMEM45A →	-0.395	-0.112	.008	<.001	3	4
PANCREAS	MLF2 →	+0.142	+0.104	.009	.005	3	4
CNS	SERPINB9 →	+0.220	+0.086	<.001	.002	3	4
SKIN	FST →	-0.143	-0.045	.001	.003	3	4
SKIN	CAST →	+0.195	+0.058	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPAP1 by Regulation of G2/MI transition of meiotic cell cycle activity — SOFT_TISSUE

Explore this box plot interactively →