DNA strand resection involved in replication fork processing

Across TCGA patient cohorts, RNA activity of the DNA strand resection involved in replication fork processing pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are G3BP1P1, IFI27L1, and KIF18A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA strand resection involved in replication fork processing activity versus G3BP1P1 in LSCC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	G3BP1P1 →	+0.757	+0.638	<.001	<.001	3	4
BRCA	IFI27L1 →	+0.449	+0.652	.003	<.001	3	4
PDAC	KIF18A →	+0.527	+0.593	.001	<.001	3	3
CCRCC	ORMDL2 →	+0.222	+0.686	.007	<.001	3	3
LSCC	ZNF516-DT →	+0.240	+0.507	<.001	.002	3	3
LSCC	SLIRP →	+0.491	+0.474	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110025 vs G3BP1P1 — LSCC

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