DNA strand resection involved in replication fork processing

Across TCGA cell cohorts, RNA activity of the DNA strand resection involved in replication fork processing pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAD50, CAMLG, and APPL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA strand resection involved in replication fork processing activity versus RAD50 in URINARY_TRACT (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RAD50 →	+0.938	+1.509	.003	.001	3	6
LUNG_NSCLC_LUAD	CAMLG →	+0.668	+0.976	<.001	<.001	3	6
URINARY_TRACT	APPL1 →	+0.816	+1.525	.001	<.001	3	5
URINARY_TRACT	C5orf24 →	+1.416	+1.750	<.001	.004	3	5
LUNG_NSCLC_LUAD	ASH2L →	+0.469	+0.693	.003	.003	3	5
LARGE_INTESTINE	TMEM120A →	+0.626	+1.096	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110025 vs RAD50 — URINARY_TRACT

Explore this scatter interactively →