Regulation of actomyosin structure organization

Across TCGA cell cohorts, RNA activity of the Regulation of actomyosin structure organization pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R13L, HSPD1, and TMPRSS13, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of actomyosin structure organization activity versus PPP1R13L in OVARY (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PPP1R13L →	+1.407	+0.273	.008	.001	2	9
PANCREAS	HSPD1 →	-1.009	-0.442	.001	<.001	3	8
STOMACH	TMPRSS13 →	+2.458	+0.286	.002	<.001	3	7
BREAST	NHEJ1 →	-0.693	-0.217	.004	.004	3	7
LIVER	TSPAN15 →	+1.677	+0.252	.006	.004	3	7
PANCREAS	TTL →	-1.097	-0.327	.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110020 vs PPP1R13L — OVARY

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