Regulation of basement membrane organization

Across TCGA patient cohorts, RNA activity of the Regulation of basement membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EP300, USP34, and SMG1, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of basement membrane organization activity versus EP300 in DLBC (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	EP300 →	+1.563	+0.053	<.001	<.001	3	33
THYM	USP34 →	+1.766	+0.083	<.001	<.001	3	33
DLBC	SMG1 →	+1.347	+0.053	<.001	<.001	3	33
DLBC	BOD1L1 →	+1.803	+0.078	<.001	<.001	3	33
THYM	HIVEP1 →	+1.336	+0.082	<.001	<.001	3	33
THYM	DICER1 →	+0.947	+0.075	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110011 vs EP300 — DLBC

Explore this scatter interactively →