Regulation of basement membrane organization

Across TCGA patient cohorts, RNA activity of the Regulation of basement membrane organization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EFEMP2, ISLR, and OLFML1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of basement membrane organization activity versus EFEMP2 in LSCC (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EFEMP2 →	+0.662	+0.107	<.001	<.001	3	10
OV	ISLR →	+0.895	+0.116	<.001	<.001	3	10
UCEC	OLFML1 →	+0.928	+0.087	<.001	<.001	3	10
BRCA	PCOLCE →	+0.831	+0.097	<.001	<.001	3	10
OV	TNS2 →	+0.515	+0.107	<.001	<.001	3	10
BRCA	HSPA12B →	+0.665	+0.093	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110011 vs EFEMP2 — LSCC

Explore this scatter interactively →