Regulation of basement membrane organization

Across TCGA cell cohorts, RNA activity of the Regulation of basement membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNPEP, ELOVL6, and ZNF524, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNPEP grouped by Regulation of basement membrane organization-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DNPEP →	-0.659	-0.872	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	ELOVL6 →	-2.960	-1.938	<.001	<.001	3	4
KIDNEY	ZNF524 →	+0.705	+1.366	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	TSC1 →	-1.387	-1.589	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	PLCG1 →	-1.479	-1.282	.002	.001	3	4
UPPER_AERODIGESTIVE_TRACT	ARFGAP2 →	-1.103	-1.383	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNPEP by Regulation of basement membrane organization activity — CNS

Explore this box plot interactively →