Regulation of basement membrane organization

Across TCGA cell cohorts, RNA activity of the Regulation of basement membrane organization pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDC1, NDUFS7, and CADM2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDC1 grouped by Regulation of basement membrane organization-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NDC1 →	+0.142	+1.652	.005	<.001	3	3
BREAST	NDUFS7 →	-0.330	-1.123	.008	.005	3	3
LUNG_SCLC	CADM2 →	-0.152	-1.121	.001	.005	3	3
LARGE_INTESTINE	THNSL1 →	-0.203	-1.151	.009	.006	3	3
LARGE_INTESTINE	TM9SF3 →	-0.164	-1.104	.004	.006	3	3
LARGE_INTESTINE	RASGEF1C →	-0.224	-1.294	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDC1 by Regulation of basement membrane organization activity — SKIN

Explore this box plot interactively →