Basolateral protein secretion

Across TCGA cell cohorts, RNA activity of the Basolateral protein secretion pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AP1B1, D2HGDH, and ARHGAP17, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Basolateral protein secretion activity versus AP1B1 in PANCREAS (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	AP1B1 →	+0.627	+0.738	.001	.001	3	4
BLOOD_Leukemia	D2HGDH →	+0.903	+0.359	<.001	.006	3	4
BLOOD_Leukemia	ARHGAP17 →	+0.888	+0.239	<.001	.006	3	4
LUNG_SCLC	ZMAT5 →	+0.681	+0.730	.001	.002	3	3
BLOOD_Leukemia	POLR2E →	+0.456	+0.359	.001	.005	3	3
BLOOD_Leukemia	RASSF4 →	+3.311	+0.337	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110010 vs AP1B1 — PANCREAS

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