Purine ribonucleotide salvage

Across TCGA patient cohorts, RNA activity of the Purine ribonucleotide salvage pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADA, AMPD3, and PLOD1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine ribonucleotide salvage activity versus ADA in GBM (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ADA →	+0.689	+0.079	<.001	<.001	3	9
GBM	AMPD3 →	+0.548	+0.051	<.001	<.001	3	8
CCRCC	PLOD1 →	+0.532	+0.044	<.001	.001	3	8
CCRCC	CRTAP →	+0.391	+0.055	<.001	<.001	3	8
OV	IKBIP →	+0.464	+0.031	<.001	.001	3	7
GBM	P3H1 →	+0.466	+0.037	.006	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106380 vs ADA — GBM

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