Purine ribonucleotide salvage

Across TCGA patient cohorts, RNA activity of the Purine ribonucleotide salvage pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF2RB, PIK3CG, and CRTAM, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine ribonucleotide salvage activity versus CSF2RB in UCEC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CSF2RB →	+1.010	+0.155	<.001	<.001	3	6
UCEC	PIK3CG →	+0.907	+0.175	<.001	<.001	3	6
HNSC	CRTAM →	+0.674	+0.153	<.001	<.001	3	6
HNSC	CD48 →	+0.910	+0.162	<.001	<.001	3	6
UCEC	CASP10 →	+0.704	+0.143	.006	.003	3	6
GBM	FCGR2B →	+0.926	+0.146	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106380 vs CSF2RB — UCEC

Explore this scatter interactively →