Purine ribonucleotide salvage

Across TCGA cell cohorts, RNA activity of the Purine ribonucleotide salvage pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADSL, AMPD3, and APRT, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADSL grouped by Purine ribonucleotide salvage-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ADSL →	-0.463	-0.663	<.001	.003	3	12
BONE	AMPD3 →	-0.351	-1.498	.007	.001	3	7
BLOOD_Leukemia	APRT →	-0.518	-1.660	<.001	<.001	3	7
CNS	AMPD1 →	-0.180	-0.842	.001	<.001	3	6
OVARY	ARL13B →	-0.149	-1.191	.004	<.001	3	5
LIVER	CDC37 →	-0.362	-1.290	.005	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADSL by Purine ribonucleotide salvage activity — STOMACH

Explore this box plot interactively →